The Important 0.1 Percent

(Nineteenth in a series of topical blogs based on chapter by chapter excerpts from Opiate Nation. Translation into most languages is available to the right.)

DNA sequences for any human is approximately 99.9 percent identical to every other human. That means that only 0.1 percent of our genetic makeup is unique to us. Genes are functional units of DNA that make up the human genome. But don’t be fooled into thinking that 0.1 percent variation is insignificant. It is nearly 3 billion base pairs of DNA which boils down to 3 million differences that determine our physical features like hair and eye color and health risks or protection from diseases such as heart disease, diabetes – and addiction. Genes influence the numbers and types of receptors in peoples’ brains, how quickly their bodies metabolize drugs, and how well they respond to different medications.

The National Institute of Drug Abuse (NIDA) reports that family studies that include identical twins, fraternal twins, adoptees, and siblings suggest that as much as half of a person’s risk of becoming addicted to nicotine, alcohol, or other drugs depends on his or her genetic makeup. Scientists estimate that genes – including the effects environmental factors have on a person’s gene expression, called epigenetics – account for between 40 and 60 percent of a person’s risk of addiction.

Epigenetics – epi meaning “above” – is the study of functional, and sometimes inherited, changes in the regulation of gene activity and expression that are not dependent on gene sequence. This means exposures or choices people make can actually “mark” (remodel) the structure of DNA at the cell level. So epigenetic regulatory systems enable the development of different cell types (e.g., skin, liver, or nerve cells) in response to the environment. These epigenetic marks can affect health and even the expression of the traits passed to children. For example, when a person uses cocaine, it can “mark” the DNA, increasing the production of proteins common in addiction which is believed to correspond with drug-seeking behaviors.

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Guest Post

Fellow WordPress blogger, mechanical engineer, artist David Such has written a review of Opiate Nation and posted it on his blog site, Memoirs and Musings. Along with the review, David included some of his pen and ink drawings of our son, JL, and John and me. We feel honored and grateful for David’s desire to help reduce stigma and shame by bringing attention to the opioid epidemic that continues to steal the lives of our sons, daughters and loved ones.

I recently finished reading Opiate Nation: A Memoir of Love, Loss, and Acceptance, by Jude DiMeglio Trang (with John M. Trang). I admit, this book was a difficult journey to travel.

Jude and John’s son, John Leif Trang (“JL”) battled various addictions from his early teen years. This story chronicles JL’s long and difficult struggle in and out of recovery up to his accidental heroin overdose and death at the age of twenty-five, and the long road through grief to emotional recovery for Jude and John that followed. Throughout the book, she includes excerpts from their private journals which provide an extremely personal perspective. She offers comfort and sage advice for others who may find themselves in a similar situation. The book takes you on a strenuous path, but is very well written and places the reader within all the confusion, family dynamics, regrets, and mixed emotions they experienced throughout this journey. The narrative is eloquently written, yet raw and purposefully honest in a bold attempt to shine a bright light on this “secret epidemic” that has destroyed many lives across North America and around the globe.

Jude is no stranger to grief. She had previously lost two brothers and a sister to premature death. The loss of JL would have been the final blow to anyone else who did not have a strong spiritual foundation. Don’t worry, though, she offers none of the trite Christian platitudes. John and Jude’s confusion and frustration are palpable. She is transparently honest about their generational family dysfunction as well as their own perceived failings as parents. Her authenticity is refreshing.

Readers will note that Jude is well-read, quoting relevant wisdom from sages throughout the centuries, from Leonardo da Vinci to C. S. Lewis, and from Beethoven to Bob Dylan. Numerous apt analogies help those not living with addiction to understand the nature of the struggle. I personally appreciated her intellectual rabbit trails into topics like the nature of time, and the physiology of memories. I also like the way she weaves together connected events throughout the years rather than marching through a dry chronological sequence. However, be forewarned, Jude does not hold back in her discussion of reality. Some of it is horrifying, but be reassured that the final chapter, “Stories of Hope,” is the reader’s opportunity to slowly exhale.

This book is a must-read for anyone who knows someone who struggles with drug addiction and/or alcoholism. However, the basic takeaway for all of us, even for those who consider themselves or their loved ones immune from addiction is this: The culture of “pain management at any cost” produces large profits for pharmaceutical companies (“Big Pharma”) at the expense of ruined lives. The default prescription for situations like a wisdom tooth extraction or a broken collar bone is almost always a heavy-duty opiate. Medical doctors “rubber stamp” these prescriptions every day. See the content of the book for details. PLEASE, don’t just fill a prescription because the doctor recommends it, especially if there is any family history of substance abuse or alcoholism. Search for safe alternatives, learn that pain is not an enemy to vanquish, and only reach for the opiate “solution” as the very last option

Opiate Nation was the well-deserved winner of the 2020 “National Indie Excellence Award” for best Addiction/Recovery Book. You will not regret traveling with them through their journey.

David B. Such

https://dbsuch.wordpress.com/

Avoiding Pain

(Thirteenth in a series of topical blogs based on chapter by chapter excerpts from Opiate Nation. Translation into most languages is available to the right.)

We are living in particularly precarious times – for people born since WWII, unprecedented problems the world over – seemingly beyond our ability to control or to deal with effectively. With the Coronavirus pandemic, complex problems have arisen for our global society to attempt to solve, from the manufacturing and transport of medical supplies and personal protective equipment to the best medical treatments and the development of a vaccine – which is viewed by many as the magic potion but only if the majority of people could be convinced to ‘get the jab.’

During this extraordinary year pain has come into most of our lives in ways we have not experienced previously: physical pain from contracting Covid19, emotional pain from being isolated or from watching those we know or care for becoming sick and dying, and mental pain from the anxiety caused by all the unknowns surrounding the pandemic. For people living in poverty, these problems are compounded.

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What’s Inside the Shell?

(Ninth in a series of topical blogs based on chapter by chapter excerpts from Opiate Nation. Translation into most languages is available to the right.)

Shells are beautiful and fascinating to me. Each and every one is unique, differing from others just like our fingerprints. John and I just spent time at the central eastern coast of Australia and on our daily walks on the beach I just couldn’t stop picking up shells – especially the Nautilus shells with their logarithmic spirals of every size, shape, and color. These are empty shells that were once the home of a sea creature.

The exoskeleton of mollusks is the hard, outer layer that protects the tender creature inside. As the creature grows, layers are added to accommodate it. One day, as I was picking up shells in the surf, the inhabitant was still inside. It immediately retreated as far back into its shell as possible.

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Science Fiction and Self-Protection

(Sixth in a series of topical blogs based on chapter by chapter excerpts from Opiate Nation. Translation into most languages is available to the right.)

I have always loved Star Trek. From the early 1960’s shows with the corny scripts and goofy hairdos to the 21st century high-tech and high-stakes extravaganzas. Science fiction envisions the future for us and pushes inventions and technology from getting “beamed-up” in a flash to having a force field to deflect foreign objects.

The concept of a force field would be an incredible tool to have at our disposal – to be able to switch it on and off at will. And I can think of no better time to employ an emotional force field than during the early days and weeks after a sudden death. When it takes all your energy just to exist, to wake up and to face the next moment. An invisible barrier for self-protection.

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Lifespan of Heroin & Opioid Addicts

(Second in a series of topical blogs based on chapter by chapter excerpts from Opiate Nation. Translation into most languages is available to the right. If you feel this blog is important, please repost to your social media using the buttons below. Thank You!)

When our 25 yr old son died of a heroin overdose in 2014, the statistics for the average life-span of a heroin addict was 5 years. Five years. Not very long if you are 15 or 20 or even 30, the age when most young adults’ nowadays are just getting in gear with their career, a long-term relationship, and planning a family. To have your life swept away before you have a chance to experience some of the most wonderful years of living on this earth is painful to consider.

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Woefully Unprepared

(Today begins a series of topical blogs based on excerpts from Opiate Nation, chapter by chapter, that will run for 28 weeks. Translation into most languages is available to the right.)

It’s a bit ironic that as I begin blogging through Opiate Nation we are in the midst of a pandemic. Ironic in several significant ways.

Opiate Nation was written because of the opioid epidemic – which, in reality, is a pandemic. Every industrialized nation, and many emerging and third-world nations too, are dealing with the results from the ease of availability of opioids, whether natural and home-grown, or synthetic and imported. Or both, as is the case in America.

And like the Coronavirus pandemic that crept up on us so gradually that it’s deadliness caught us by surprise and mostly unprepared as nations, the opioid epidemic crept up on us too. In both cases, certain international players were unscrupulous for various reasons, causing delays in awareness when there might have been a chance for all of us to not be caught off balance.

The “inoculation” that should have happened, especially in the United States, by way of accurate scientific information disseminated by responsible leaders, didn’t happen. Instead, false information fueled by political agendas and financial motivation created a scenario that so crippled a timely public health response that, for many nations, it became too little too late.

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If my son were alive today during the Covid-19 pandemic…..

I would fear for his life more than ever.

“Drug Overdoses Soaring: Suspected overdoses nationally jumped 18% in March, 29% in April, 42% in May, data from ambulance teams, hospitals, and police shows.”

As a young man in America who wanted more than anything to be free of his deadly heroin addiction, how would he be weathering the Covid-19 pandemic?

“The drug-overdose-and-death epidemic already was hurting communities before COVID-19, but during the pandemic there have been reports from every region of the country on spikes in opioid-related calls to first responders, visits to emergency rooms, fentanyl and tainted-drug-related overdoses. There also have been challenges to accessing sterile needle and syringe and exchange services.”

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AIRING DIRTY LAUNDRY?

When I was growing up, this metaphor was commonly espoused: “Don’t air your dirty laundry in public.” That is, you shouldn’t reveal things from your private life that people usually don’t want others to know and they don’t want to hear anyway. Things like inappropriate confessions and unpleasant family secrets. Everyone will be embarrassed and people will feel ashamed.

Now we are more likely to hear someone respond with “TMI – Too much information” when someone goes beyond the bounds of information that no one wants to hear – either too creepy or medical or personal. Totally understandable.

But is it airing dirty laundry for us to speak openly about conditions or situations that are of a communal nature? Topics such as physical or sexual abuse, or complicity and criminal behavior by politicians or leaders, or suicide, or addiction? Of course, there are some details about issues that plague us as a community that do not need to be  part of the public discussion in certain situations. But that is different than bringing an issue into the light of day so that it can be discussed in order to work towards a solution.

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Handwriting on the Wall

The other day I was thinking about our son and his struggles with drugs and alcohol and all that we know and understand now compared to what we knew and understood in the early 2000’s right up until his death in 2014. I saw myself, as if I were standing out in an open field, turning, looking back over my shoulder. That’s what I do when something unexpected or disturbing happens. I look back and try to figure out what I missed, what I could have done differently.

My next thought was: Why couldn’t my husband and I see the handwriting on the wall? Why didn’t we realize how dire the situation was at every new juncture with our son as the years went by? But, I realized that it wasn’t that we couldn’t see the handwriting on the wall. It was that we didn’t understand what it meant.

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